First single-cell macrophage atlas across the lifespan of a human cardiac allograft

Published in Circulation, we report the first single-nucleus RNA-seq atlas of macrophages across the lifespan of a pediatric cardiac allograft. The work shows that donor-derived macrophages are rapidly replaced by recipient cells after transplantation and identifies targets for tailored immunomodulation to improve long-term allograft survival. Read the paper. · Texas Heart Institute press release.